eBook Chapter Summary

Chapter 7. On-line derivatisation/degradation

doi: 10.1255/978-1-906715-15-1_ch7
Pages 215–236

A Handbook of Derivatives for Mass Spectrometry

by Vladimir Zaikin and John Halket

Chapter Summary

Chemical or physical–chemical conversion, however, may be accomplished directly in the inlet system of a mass spectrometer (on-line). Such a procedure can permit the analysis of sub-microgram amounts of compound, which are accessible to mass spectrometric detection; it also saves time by eliminating the need for a separate derivatisation step.